Gliomatosis cerebri: Case series of six cases with review of literature

Abstract

ABSTRACT Background Gliomatosis cerebri is characterized by diffuse infiltration of glial cells with preservation of neuronal architecture. It is an uncommon glial neoplasm of astrocytic origin that occurs in adults and is exceedingly rare in children. Materials and Methods: The authors retrospectively analyzed the data of 6 patients of gliomatosis cerebri operated between 2007 and 2012. Result: All patients underwent surgical decompression, followed by chemoradiotherapy. The survival ranged between 3 and 45 months. The mean survival was 18.5 years. Conclusion: Performance scores at presentation and the nonglioblastomatous histology seems to favorably affect the prognosis. Larger studies are required to comment on the role of combination of surgery, chemoradiotherapy as a treatment modality.