Histopathology of a polyploid laryngeal growth revealing disseminated histoplasmosis

Abstract

Abstract Any polyploid growth in the laryngeal region may be mistaken for a malignant condition. Histoplasmosis of the larynx rarely causes laryngitis; it often masquerades as malignancy or tuberculosis. The other name of this condition is “Cave’s disease” and is caused by the fungus, Histoplasma capsulatum. Here, we report a 54-year-old diabetic male who presented with a history of progressive hoarseness of voice for 6 months. The patient was a chronic smoker for 15 years. A biopsy of the growth was done, and a histopathological examination of the tissue clinched the diagnosis of laryngeal histoplasmosis. The patient was managed with intravenous liposomal amphotericin B and oral itraconazole with complete resolution of symptoms.