Affiliation:
1. Department of Cardiology, School of Medicine, Urmia University of Medical Science, Urmia, Iran
2. Medical Center, Urmia University of Medical Science, Urmia, Iran
3. Department of Dermatology and Infectious Disease, School of Medicine, Urmia University of Medical Science, Urmia, Iran
Abstract
Objective:
To investigate cardiovascular risk factors affecting COVID-19 outcomes in a tertiary referral hospital.
Methods:
This prospective cohort study analyzed 269 participants with COVID-19. The primary outcomes were ICU admission, prolonged hospital stay duration, and in-hospital death. The secondary outcomes included death, chronic symptoms, and NYHA functional class during follow-up periods.
Results:
A total of 412 patients with COVID-19 symptoms were enrolled in the study, and out of which 269 patients had complete medical records and positive SARS-CoV-2 PCR test results, fulfilling the study criteria were analyzed. The patients were divided into two groups, with cardiovascular comorbidities (group A, n=122), such as established cardiovascular disease, diabetes mellitus, and hypertension, and without cardiovascular comorbidities (group B, n=147). Binary logistic regression analysis showed that patients with underlying hypertension, diabetes, and established cardiovascular disease had a 1.55 (95% CI: 1.28-2.26), 1.62 (95% CI: 1.34-2.13), and 1.63 (95% CI: 1.07-5.34)-fold risk of mortality, respectively in the adjusted model.
Conclusions:
Hospitalized COVID-19 patients with predisposing cardiovascular risk factors are more susceptible to develop worse outcomes. More attention should be paid to the management and follow-up of these patients.