An Angiotensin-converting Enzyme Inhibition Activity by Various Natural Approaches: A Statistic Review

Abstract

The most prevalent cardiovascular illness in the world, hypertension, is a significant public health issue in both developed and developing nations. A major risk of cardiovascular disease and high blood pressure is morbidity and mortality. Among all the classes of antihypertensive drugs, angiotensin-converting enzyme (ACE) inhibition has been considered an effective therapeutic approach for the management of hypertension. ACE catalyzes the conversion of inactive angiotensin I into a potent vasoconstrictor, angiotensin II. Angiotensin II results in raising blood pressure by increasing peripheral resistance, heart rate, and cardiac output. There are a number of disorders associated with the cardiovascular system which is frequently treated with ACE inhibitors. Nowadays, various synthetic ACE inhibitors are used in clinical use to treat hypertension. There have been numerous negative side effects related to synthetic ACE inhibitors. Look for natural resources that can be exploited to produce ACE inhibitors that are reliable, safe, benign, and more cost-effective approaches. This review focuses on ACE inhibitors from natural source for the control hypertension. Additionally, a valid statistical analysis of data using a one-sample t-test on data that was collected at random and valued looks at whether the sample's mean is statistically different from or equal to a known or predicted mean value.