Synchronous Occurrence of Adult Granulosa Cell Tumor with Fibroma in One Ovary and Brenner Tumor in Other Ovary: An Extremely Unusual Case

Author:

Yadav Alka1,Pujani Mukta1,Singh Kanika1,Chauhan Varsha1,Singh Aparna1,Sharma Jagadish Chandra2

Affiliation:

1. Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India

2. Department of Obstetrics and Gynaecology, ESIC Medical College and Hospital, Faridabad, Haryana, India

Abstract

ABSTRACT Ovarian tumors are a common form of neoplasia in women and it accounts for about 30% of female genital cancers. A coexistence of ovarian tumors with the same histogenetic origin such as germ cell or epithelial or sex cord stromal, but different histologic subtype is relatively common, whereas a synchronous occurrence of tumors with different histogenetic origin is rare. We report a case of 58-year-old woman with the synchronous presentation of adult granulosa cell tumor with fibroma (ovarian tumors with the same origin (sex cord stromal) but different histologic type) in one ovary and Brenner tumor (epithelial origin) in other ovary. Our patient presented with postmenopausal bleeding and was diagnosed with this rare combination of ovarian tumors on histopathology supplemented with immunohistochemistry. On extensive literary search, there is only a single report of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor. Our case is different from the above-mentioned report as although, in our patient both tumors coexisted, but in contralateral ovaries.

Publisher

Medknow

Subject

Health (social science),Medicine (miscellaneous)

Reference7 articles.

1. Benign Brenner tumor of ovary-A rare case report;Tiwari;IAIM,2018

2. Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma:A case report;Semczuk;Eur J Gynaecol Oncol,2011

3. Aclinicopathological study of granulosa cell tumors of the ovary:Can morphology predict prognosis?;Guleria;Indian J Pathol Microbiol,2020

4. Granulosa cell tumor of the ovary:A retrospective study of 31 cases and a review of the literature;Dridi;Int J Surg Oncol,2018

5. Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests:A study of 120 tumors;Seidman;Arch Pathol Lab Med,2008

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