1. Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), and Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal
2. Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal
3. Univ Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, Coimbra, Portugal (Almeida-Ferreira C) Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal
4. Univ Coimbra, Institute of Integrated Clinical Practice and Laboratory for Evidence-Based Sciences and Precision Dentistry, Coimbra, Portugal; Univ Coimbra, Institute of Experimental Pathology, Faculty of Medicine, Coimbra, Portugal; Univ Coimbra, Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), Advanced Production and Intelligent Systems (ARISE), Coimbra, Portugal