CYP2C9 Genotype and Phenotype Profile of Cross-Country Skiing Athletes

Abstract

Aim: Most tissues in the body contain cytochrome P450 enzymes, which play an important role in many functions, especially metabolizing drugs and other xenobiotics. The CYP2C9 gene in humans codes for an enzyme called CYP2C9. The goal of this study was to figure out the genotype and allele distributions of the CYP2C9 gene rs1799853 (CYP2C9*2), rs1057910 (CYP2C9*3), rs28371686 (CYP2C9*5) and rs28371685 (CYP2C9*11) polymorphism in our cohort study. Materials and Methods: For this purpose, 19 cross-country skiing athletes took part in our research. After DNAs were extracted from buccal epithelial cells, real-time polymerase chain reaction was used to genotype them. Results: When we looked at the genotype distributions, we found that, the CC genotype was higher than CT and TT genotype for CYP2C9*2. For CYP2C9*3, the AA genotype was higher than the AC genotype and no CC genotype was found. Besides for the CYP2C9*5, only the CC genotype was found. In addition, only the CC genotype was found for CYP2C9*11. For The genotypic and predictive phenotype distribution of CYP2C9 polymorphisms, it was determined that 11 athletes (57.9%) were *1/*1 (extensive metabolizers), and 5 athletes (26.3%) were *1/*2 (intermediate metabolizers). As a poor metabolizer, one athlete *2/*2 (5.3%) and two athlete *2/*3 (10.5%) were determined. Conclusion: This study is the first study investigating the relationship between the CYP2C9 polymorphism in Turkish cross-country skiing athletes.