Efficacy of preoperative melatonin versus pregabalin on intraoperative anxiolysis and sedation during hip arthroplasty under regional anesthesia

Abstract

Background and objectives Anesthesiology places a high priority on perioperative anxiety, pain, and its consequences and much research has been conducted to reduce or remove them. Postoperative sleep disruption is increased by postoperative pain. Also, sleep disruption exacerbates postoperative pain. In this clinical trial, we aim to explore the efficacy of melatonin and pregabalin on anxiolysis, sedation and postoperative pain in patients undergoing hip arthroplasty under spinal anesthesia. Material and methods Patients were randomly assigned into three groups, each including 26 patients. group M patients received melatonin 10 mg, while group G patients received pregabalin 150 mg, and group C patients received 5 mg of melatonin plus 75 mg of pregabalin. This study was started on January 2022 and completed in October 2022. Results VAS score reading is significant when comparing readings of group1& 2 and when comparing readings of groups 2 to group 3 but not significant at all when comparing groups 1 to 3 (VAS at last reading P1 0.005, P2 0.005 and at highest reading P1 0.00, P3 0.00). Sedation score is not significant in the 3 groups when comparing 1st, the last, and highest reading. Conclusion When comparing pregabalin to melatonin for intraoperative sedation and postoperative sedation and analgesia, it was found that pregabalin has the upper hand for postoperative analgesia and both were equal effectiveness for sedation.