Roles of Triggering Receptor Expressed on Myeloid Cells-1: More than Just Pneumonia-Reference-Cited by-同舟云学术

Roles of Triggering Receptor Expressed on Myeloid Cells-1: More than Just Pneumonia

Published:2024 Issue:1 Volume:14 Page:18-24
ISSN:2321-8568
Container-title:Advances in Human Biology
language:en
Short-container-title:

Author:

Han Jiajia¹,Li Li²

Affiliation:

1. Department of Respiratory Medicine, Yanan University, Yulin, Shaanxi, China

2. Yanan, Shaanxi, Yulin First Hospital, Yulin, Shaanxi, China

Abstract

Triggering receptor expressed on myeloid cells (TREM)-1 is a transmembrane receptor embedded in the intrinsic immune cell membrane that amplifies inflammation by increasing inflammatory signalling triggered by toll-like receptors as well as transcript levels in the NF-κB signalling pathway. The soluble form of TREM-1 is obtained by cleavage of the extracellular portion of TREM-1 by matrix metalloprotease-9 and can be used as a biomarker for the diagnosis and prognosis of TREM-1 pathway activation in many acute and chronic inflammatory diseases. The present review aims to summarise the latest research and insights on TREM-1 in inflammatory and non-inflammatory diseases.

Publisher

Medknow

Subject

Ocean Engineering

Reference61 articles.

1. TREM-1 isoforms in bacterial infections: To immune modulation and beyond;Matos;Crit Rev Microbiol,2021

2. The role of the triggering receptor expressed on myeloid cells-1 (TREM-1) in non-bacterial infections;de Oliveira Matos;Crit Rev Microbiol,2020

3. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily;Cantoni;J Exp Med,1999

4. Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes;Bouchon;J Immunol,2000

5. Transepithelial migration of neutrophils into the lung requires TREM-1;Klesney-Tait;J Clin Invest,2013