Epithelioid Hemangioendothelioma of Nasal Cavity

Author:

Patnayak Rashmi1,Jena Amitabh2,Reddy M Kumaraswamy1,Chowhan Amit kumar1,Rao LM Chandrasekhar2,Rukhamangadha N1

Affiliation:

1. Department of Pathology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

2. Department of Surgical Oncology, Sri Venketeswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Abstract

ABSTRACTWe present a rare case of epithelioid hemangioendothelioma (EHE) in the nasal cavity of a 40-year-old Indian male who presented with history of intermittent epistaxis. The lesion was tested for a panel of immunohistochemical markers like vimentin, CD31, CD34, Factor VIII, vascular endothelial growth factor (VEGF) and Ki67. Immunohistochemically, the neoplasm showed striking positivity for vimentin, CD31, CD34 and weak positivity for VEGF; positivity was also noted for Factor VIII especially in the miniature intracytoplasmic vascular lumina.

Publisher

Georg Thieme Verlag KG

Reference5 articles.

1. Barnes EL, Eveson JW, Reichart P, Sidransky D. Pathology and Genetics of Head and Neck Tumours. Kleihues P, Sobin LH, editors. World Health Organization Classification of Tumours. Lyon. France: IARC Press; 2005.

2. Weiss SW, Goldblum JR. Hemangioendothelioma:Vascular tumors of Intermediate malignancy. In: Enzinger and Weiss′s Soft tissue tumors. 5 th ed. Philadelphia. PA: Mosby- Elsvier; 2008. P. 681-702.

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