Adjunctive Use of Autologous Platelet Concentrates in Surgical Management of Periodontal Osseous Defects

Abstract

The autologous platelet concentrates (APC) comprise of platelet rich plasma (PRP) and platelet rich fibrin (PRF). These platelet concentrates provide a rich source of growth factors and have been used alone or in combination with bone grafts (BG) during open flap debridement (OFD) to treat various periodontal osseous defects. This literature review was performed to assess the effect of adjunctive use of autologous platelet concentrates (APC) in the surgical management of periodontal osseous defects. Literature search was performed through the databases of national library of medicine and EBSCO host using PubMed and Google scholar search engines and manual searches in which 36 randomized clinical trials (RCT) meeting inclusion criteria that evaluated the healing outcomes of Probing depth (PD) reduction, gain in clinical attachment level (CAL), radiographic bone fill and defect fill in intervention of OFD+APC / OFD+BG +APC as compared to OFD/ OFD+BG in the treatment of periodontal osseous defects published between 2001 to 2019 were assessed. Upon assessment of literature the adjunctive use of APCs appears to have an additive effect to open flap debridement alone or along with bone grafts in surgical management of periodontal osseous defects.