Abstract No. : ABS2330 : Comparison of three different sedative regimens for gastrointestinal endoscopic procedures

Abstract

Background &Aims: Gastrointestinal (GI) endoscopic procedures are relatively invasive and unpleasant and need high level of patient co-operation. Aim of our study was to compare three different sedative regimens using propofol, dexmedetomidine and fentanyl-midazolam combination for safer sedation in GI endoscopic procedures. Methods: The patients who satisfied the inclusion criteria were randomly allocated into three groups of 30 each. Group P patients received propofol 1mg/kg i.v followed by 0.5mg/kg/hr infusion. Group- D received dexmedetomidine1µg/kg i.v. infusion over 10min followed by 0.5µg/kg/hr infusion. Group- FM received fentanyl 1µg/kg and midazolam 20 µg/kg i.v. followed by fentanyl 0.5µg/kg/hr infusion. The endoscopic procedure was started when the patient attained a level of conscious sedation [score of 2-4 on the Observer Assessment of Alertness/Sedation Scale(OAA/S scale)].The patient’s and endoscopist level of satisfaction was assessed using the 10 - point visual analogue scale Results: Demographic data and the duration of the procedure between the three groups were similar and statistically insignificant. The heart rate, mean arterial pressure and oxygen saturation were lower in Group-D and were statistically significant. The onset of sedation was earlier with Group-P. The time to recovery, requirement of additional fentanyl, incidence of gagging, patient and surgeon’s satisfaction scores and maximum OAA/S score were similar in Groups D and P and better than Group-MF. Conclusion: I We conclude that dexmedetomidine provides an overall better experience for the patient, endoscopist and anaesthesiologist than propofol and midazolam-fentanyl combination.