Abstract No.: ABS2724: Correlation of peri-operative factors with immediate graft functions in renal transplant patients

Abstract

Background and Aims: The number of successful transplants has increased dramatically. Very few studies have demonstrated the effect of various peri-operative factors on the immediate graft function (IGF) after transplant. This study aimed at evaluating the various peri-operative factors affecting the IGF. JOURNAL/ijana/04.03/01762628-202203001-00068/inline-graphic1/v/2022-09-30T091728Z/r/image-tiff Methods: This was a prospective observational study performed in patients undergoing renal transplant from 2018 to 2019. The recipient population was divided into two groups: group A, live donor recipients (LD), and group B, deceased donor recipients (DD). Pre-operative parameters such as patient demographics, co-morbidities, investigations, vitals, duration of dialysis, site, and frequency were noted. Patients were induced routinely. Intra-operative factors such as vitals, episode of hypotension, need for inotropes, ischemia time, and urine output were noted. The graft outcome variables such as 24-hour urine output, creatinine, blood urea nitrogen, need for dialysis, haemoglobin and creatinine upto 6 months, need for intravenous immunoglobulin, and plasma exchange were noted. JOURNAL/ijana/04.03/01762628-202203001-00068/inline-graphic2/v/2022-09-30T091728Z/r/image-tiff Results: There was a significant difference in cold ischemia time (p = 0.000), immediate urine output (p = 0.016), post-operative values of haemoglobin (p = 0.03), potassium (p = 0.001), creatinine (p = 0.000), and creatinine at 1 month post transplant (p = 0.03) among both the groups. Factors such as pre-operative urea and haemoglobin affect 24 hour urine output in the DD group, whereas pre-operative urea, systolic blood pressure (SBP), and diastolic blood pressure (DBP) and post-operative SBP, DBP, potassium, and creatinine affect 24 hour urine output in the LD group. Conclusion: Decreasing the cold ischemia time even in deceased donor kidneys will improve the renal function in terms of urine output, electrolytes, and creatinine.