Drug rash with eosinophilia and systemic symptoms (DRESS): A report of two cases

Author:

Rama M. C. R.1,Bindhu Madhavi Gottam1,Mohan Alladi1,Prakash R. Bhanu2,Devi B. Vijayalaxmi3

Affiliation:

1. Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

2. Department of Dermatology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

3. Department of Radiodiagnosis, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Abstract

Abstract Drug Rash with Eosinophilia and Systemic Systems (DRESS) is an idiosyncratic severe cutaneous adverse reaction characterised by a skin rash with systemic involvement. DRESS syndrome can be caused by several drugs. We report two patients who presented with DRESS syndrome caused by anti-epileptic drugs lamotrigine and oxcarbazepine. Based on clinical presentation, laboratory testing and imaging findings, the patients were diagnosed to have DRESS syndrome. In both the patients, offending drugs were stopped and patients were treated with iv corticosteroids, and symptomatic treatment and had recovered.

Publisher

Medknow

Subject

General Medicine

Reference14 articles.

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4. Anticonvulsant hypersensitivity syndrome:Incidence, prevention and management;Knowles;Drug Saf,1999

5. Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome induced by celecoxib and anti-tuberculosis drugs;Lee;J Korean Med Sci,2008

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