Affiliation:
1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
Abstract
Abstract
Objective:
The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome (CLS) and to predict new prescriptions.
Materials and Methods:
The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence (AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis.
Results
The top 16 medicinals used by Professor Wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses.
Conclusions
This study summarized Professor Wang’s medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.
Subject
Complementary and alternative medicine
Reference28 articles.
1. Research progress of female climacteric syndrome;Guan;All Health (Acad Ed),2015
2. A review of climacteric syndrome;Jiao;Renowned Doct,2018
3. Epidemiological investigation on the health status of perimenopausal women in Beijing;Deng;Beijing Med J,2002
4. Effect of hormone therapy on quality of life in patients with climacteric syndrome;Yin;J Capital Med Univ,2013
5. Menopause hormone therapy:Latest developments and clinical practice;Fait;Drugs Context,2019