Serendipitous Diagnosis of Tertiary Hyperparathyroidism in a Case Purportedly thought to have Skeletal Metastases

Author:

Goel Rashi1,Jaleel Jasim1,Damle Nishikant1,Kaushik Prateek1,Gupta Rahul2,Vuthaluru Seenu3,Radhakrishnan Lakshmi3,Kumar Venkatesan Sampath4,Tripathi Madhavi1,Bal Chandrasekhar S1

Affiliation:

1. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

2. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India

3. Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India

4. Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India

Abstract

Tertiary hyperparathyroidism (THPT) is characterized by over secretion of parathyroid hormone caused by long-standing secondary hyperparathyroidism. THPT can affect the bones as well as cause extraskeletal calcifications. The bony lesions often mimic multiple skeletal metastases or multiple myeloma. We report a case of a 48-year-old man with chronic kidney disease on dialysis, who presented with chief complaints of low back ache and swelling over the left clavicle. In view of clinical suspicion of malignancy with bony metastases, he underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography and was subsequently found to have parathyroid adenomas, which were confirmed on 99mTc-methoxy-isobutyl-isonitrile scintigraphy.

Publisher

Medknow

Subject

Radiology, Nuclear Medicine and imaging

Reference7 articles.

1. Tertiary hyperparathyroidism: A review;Palumbo;Clin Ter,2021

2. Secondary and tertiary hyperparathyroidism;Jamal;J Clin Densitom,2013

3. Brown tumors mimicking bone metastases;Meydan;J Natl Med Assoc,2006

4. Secondary and tertiary hyperparathyroidism in chronic kidney disease: An endocrine and renal perspective;Chandran;Indian J Endocrinol Metab,2019

5. Pathophysiological mechanisms of vascular calcification in end-stage renal disease;Davies;Kidney Int,2001

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