Enhancement of Oral Bioavailability of Drugs through Nanotechnology: Comprehensive Review and Meta-Analysis

Abstract

In terms of drug delivery methods, oral administration stands out as the preferred option, as it ensures better patient compliance. However, the challenges of poor water solubility and limited metabolic/enzymatic stability hinder the effectiveness of oral drug delivery. Nanotechnology-based drug delivery systems offer promising solutions to overcome these barriers and enhance oral medication delivery. They provide an avenue for administering antihypertensive drugs with improved therapeutic impact and bioavailability. To compile information on enhancing oral bioavailability through nanotechnology, we conducted searches in various databases, including PubMed, Google Scholar, and ScienceDirect. We reviewed a total of 12 studies from different countries that investigated the oral bioavailability of various nanoparticles. Based on our analysis, nanotechnology-based formulations demonstrated a substantial potential for improving medication bioavailability, with a 95% confidence interval (1.08–4.30). The results of this meta-analysis indicate that a significant majority of the treatments yielded enhanced relative bioavailability.