Relationship between Helicobacter Pylori and colon cancer

Abstract

BACKGROUND: Helicobacter pylori is a Gram-negative bacteria found in the gastric epithelia of around half of the world's population. Chronic gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue, and stomach cancer are all known to be caused by this illness. Furthermore, there is evidence that bacteria are linked to a number of extragastric disorders. Since it was initially hypothesized that the link between extragastric illnesses and colon cancer. OBJECTIVE: The objective of this study was to obtain the correlation between colon cancer and H. pylori infection. METHODS: In this study, we tested blood samples were collected from the patients with colon cancer to assess the presence of anti-H. pylori infection antibodies in 10 patients with colorectal cancer and 10 with no specific pathologies as a control group. RESULTS: There was a statistically significant difference (P > 0.05) and a highly significant difference (P > 0.001) in H. pylori infection and colon cancer between patients and control, respectively. A significant correlation between H. pylori infection and colon cancer (P > 0.05) was noted. It was found to be a positive linear correlation with H. pylori infection (r = 0.436) and significant (P = 0.027). The study showed a significant correlation between age and H. pylori and colon cancer (P = 0.013 and P = 0.034, respectively). CONCLUSION: H. pylori infection is one of the risk factors that develop colon cancer. The old age correlates with increased colon cancer and H. pylori infection.