Affiliation:
1. Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Carcinosarcoma of the prostate is a rare neoplasm characterized by a sarcomatoid component coexisting with an adenocarcinoma. This tumor has a poor outcome and presents usually with distant metastasis. Immunohistochemically, the epithelial and mesenchymal components are different, and on a molecular basis, the presence of mutations of TP53 and phosphate and tensin homolog (PTEN) supports the role of epithelial-mesenchymal transition in the pathogenesis of this entity. We report the case of a 63-year-old man presented with advanced prostate carcinosarcoma showing a negative reaction for PTEN and a positive staining for P53 in both components by immunohistochemical study.