Indian clinical practice consensus guidelines for the management of laryngeal cancer: Update 2022

Author:

Singhal Manish1,Prabhash Kumar2,Babu K. Govind3,Chaturvedi Pankaj4,Kuriakose Moni5,Birur Praveen6,Anand Anil K.7,Kaushal Ashish8,Mahajan Abhishek9,Syiemlieh Judita10,Gairola Munish11,Ramachandra Prakash12,Goyal Sumit13,John Subashini14,Nayyar Rohit15,Patil Vijay M.16,Rao Vishal17,Noronha Vanita2,Roshan Vikas18,Rath G. K.19

Affiliation:

1. Department of Medical Oncology, Indraprastha Apollo Hospital, New Delhi

2. Department of Medical Oncology, Tata Memorial Hospital, Mumbai

3. Department of Medical Oncology, HCG Hospitals, Bangalore

4. Department of Surgical Oncology, Tata Memorial Hospital, Mumbai

5. Department of Head and Neck Surgery – Oncology, Mazumdar Shaw Medical Center, NH Health City, Bangalore

6. Department of Oral Medicine and Radiology, KLE Society's Institute of Dental Sciences (KLESIDS), Bangalore

7. Department of Radiation Oncology, Fortis Memorial Research Institute, Gurugram

8. Department of Medical Oncology, HCG Cancer Centre, Ahmedabad

9. Department of Radiology, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, United Kingdom

10. Department of Radiation Oncology, Civil Hospital, Shillong

11. Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi

12. Department of Radiation Oncology, Sri Shankara Cancer Hospital and Research Centre, Bangalore

13. Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi

14. Department of Radiotherapy, Christian Medical College, Vellore, Tamil Nadu

15. Department of Surgical Oncology, Max Super Speciality Hospital, New Delhi

16. Department of Medical Oncology, P D Hinduja Hospital, Mumbai

17. Department of Surgical Oncology, HCG Cancer Centre, Bangalore

18. Department of Radiation Oncology, Shri Mata Vaishno Devi Narayana Super Speciality Hospital, Jammu and Kashmir

19. Department of Radiation Oncology, All India Institute of Medical Sciences, Delhi

Abstract

In laryngeal cancer, the goal of treatment is to achieve maximum cure and preserve function of the larynx with good voice quality. In early disease, transoral laser microsurgery is the preferred choice of treatment. An option for treatment of carcinoma in situ is radiotherapy (RT). In locally advanced laryngeal carcinoma, concurrent chemoradiotherapy (CTRT) is an option. Induction therapy with docetaxel, cisplatin, and 5-flourouracil (TPF), followed by definitive RT or definitive CTRT can be one of the organ preservation approaches for patients undergoing total laryngectomy. For resectable locally advanced disease (T3, N0-3), surgery (laryngectomy with thyroidectomy, ipsilateral or bilateral neck dissection, and pretracheal and ipsilateral paratracheal lymph node dissection) with RT or CTRT should be considered.

Publisher

Medknow

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