Overexpression of Long Non-coding RNAs MCM3AP-AS1 and LINC00092 Predict Poor Prognosis in Patients with Gastric Adenocarcinoma-Reference-Cited by-同舟云学术

Overexpression of Long Non-coding RNAs MCM3AP-AS1 and LINC00092 Predict Poor Prognosis in Patients with Gastric Adenocarcinoma

Published:2024-04 Issue:1 Volume:13 Page:
ISSN:2277-9175
Container-title:Advanced Biomedical Research
language:en
Short-container-title:

Author:

Bagheri Mahdi¹,Aghaabdollahian Safieh²,Asghardoust Rezaei Milad³,Gholian Kholerdi Ali Mehdi³,Raei Mehdi¹⁴,Keyvanloo Shahrestanaki Mohammad⁵

Affiliation:

1. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

2. Faculty of Pharmacy, Damghan Branch, Islamic Azad Univercity, Damghan, Iran

3. Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

4. Department of Epidemiology and Biostatistics, School of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran

5. Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran

Abstract

Background: LINC00092 and MCM3AP-AS1 long non-coding RNAs (LncRNAs) play significant roles in the development and pathogenesis of many cancers. However, their expression levels and prognostic values were not evaluated in human gastric adenocarcinoma (GAC). Therefore, the present study aimed to investigate the clinico-pathological correlations of LINC00092 and MCM3AP-AS1, LncRNAs expression in GAC, and evaluate their prognostic values. Materials and Methods: The expression of LINC00092 and MCM3AP-AS1 was detected in 89 GAC tissues by quantitative real-time reverse-transcription PCR (qRT-PCR). Results: Our results showed that LINC00092 and MCM3AP-AS1 are overexpressed in GAC patients and positively correlated with GAC invasion and vascular, peritoneal, and lymph node metastasis (P < 0.05). Furthermore, the results indicated that MCM3AP-AS1 (P = 0.0225) and LINC00092 (P < 0.001) have positive correlations with GAC patients’ overall survival. Conclusion: Altogether, the present results indicated that LINC00092 and MCM3AP-AS1 overexpression is associated with clinico-pathological characteristic of GAC patients. In addition, both of these LncRNAs may have prognostic value for estimation of patients’ overall survival.

Publisher

Medknow

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