Manasamitra Vatakam on Scopolamine-Induced Amnesia in Female Wistar Rats-Reference-Cited by-同舟云学术

Manasamitra Vatakam on Scopolamine-Induced Amnesia in Female Wistar Rats

Published:2024-04 Issue:Suppl 2 Volume:16 Page:S1824-S1828
ISSN:0976-4879
Container-title:Journal of Pharmacy and Bioallied Sciences
language:en
Short-container-title:

Author:

Sankar A¹,Kandasamy Deepa²,Jones Sumathi³,Radhakrishan Anjuna⁴,Janaki C. S⁵,Sheriff Dhastangir⁶,Prabhu K⁷

Affiliation:

1. Department of General Medicine, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India

2. Department of Anatomy, Faculty of Medicine and Health Sciences, Quest International University, Ipoh Perak, Malaysia

3. Department of Pharmacology and Therapeutics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

4. Department of Microbiology, Faculty of Medicine, Quest International University, Ipoh Perak, Malaysia

5. Department of Anatomy, Bharath Medical College and Hospital, Chennai, Tamil Nadu, India

6. Department of Biochemistry, Anna Medical College, Montangne Blance, Mauritius

7. Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

Abstract

ABSTRACT Background: Neurodegenerative diseases induce amnesia, and effective treatment is still elusive. Aims and Objectives: The present study highlights the ameliorating effects of Manasa Mitra Vatakam (MMV) using behavioral parameters on scopolamine-induced memory loss in female Wistar rats. Materials and Methods: MMV was compared with DPZ as a standard in the present study to determine the behavioral parameters through elevated plus maze (Hebb William maze/rectangular maze)and locomotor activity in scopolamine-induced memory loss in female Wistar rats. Results and Discussion: The results of the study illustrate the effectiveness of MMV in reversing memory dysfunction and memory-enhancing effects. Conclusion: The study paves the way for exploring research in CNS disorders and its potential application in drug-induced neurotoxicity.

Publisher

Medknow

Reference9 articles.

1. Preliminary GC-MS anlaysis and antioxidant study of one Ayurvedic medicine “ManasaMitraVatakam”. Int;Sivakumaran;J. Pharm. Sci. Rev. Res,2016

2. Antiamnesic Effects of walnuts consumption on scopolamine-induced memory impairments in rats;Harandi;Basic Clin Neurosci,2015

3. In vivo investigations on the cholinesterase-inhibiting effects of tricyclic quinazolinimines:Scopolamine-induced cognitive impairments in rats are attenuated at low dosage and reinforced at higher dosage;Appenroth;Pflugers Arch,2008

4. Scopolamine effects on functional brain connectivity:A pharmacological model of Alzheimer's disease;Bajo;Sci Rep,2015

5. A comparative study of neuroprotective effect of angiotensin converting enzyme inhibitors against scopolamine-induced memory impairments in rats;Jawaid;J Adv Pharm Technol Res,2015