Historical perspectives of glucagon’s discovery and early research

Author:

Brahmachari Debashish1,Masood Shabeen Naz2,Aziz Umaira3,Milenkovic Tatjana4,Chawla Manoj5,Unnikrishnan A G6,Ghosh Sujoy7,Raposo João8,Saboo Banshi9,Mohan Viswanathan10

Affiliation:

1. Department of Medical Sciences, Scientific Publishing Group, New Delhi, India

2. Department of Obstetrics and Gynecology, Isra University, Karachi, Pakistan

3. Emirates Health Services, Ibrahim bin Hamad Obaidullah Hospital, Ras Al-Khaimah, UAE

4. Department of Endocrinology, Diabetes and Metabolic Disorders, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje, Republic of North Macedonia

5. Department of Diabetology, P.D. Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India

6. Chellaram Diabetes Institute, Pune, Maharashtra, India

7. Department of Endocrinology, Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal, India

8. Nova Medical School, New University of Lisbon, Lisbon, Portugal

9. Department of Diabetology, Diabetes Care & Hormone Clinic, Ahmedabad, Gujarat, India

10. Department of Diabetology, Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialties Centre, Chennai, Tamil Nadu, India

Abstract

Abstract This review article looks at the historical journey of the discovery of glucagon and the initial stages of research that paved the way for a comprehensive understanding of its physiological significance. Glucagon, an essential peptide hormone produced by the pancreas, plays a pivotal role in maintaining glucose homeostasis. Tracing the trajectory of its discovery from its initial identification to the unraveling of its complex functions, this article offers a detailed analysis of the early scientific endeavors, and collaborations that contributed to shaping our understanding of glucagon’s pivotal role. By exploring the historical context, controversies, and advancements, this review sheds light on the evolution of endocrinological knowledge and its profound implications for diabetes research and treatment strategies.

Publisher

Medknow

Reference16 articles.

1. Preparation of insulin;Fisher;Am J Physiol,1923

2. Delayed manifestation of the physiological effects of insulin following the administration of certain pancreatic extracts;Collip;Am J Physiol,1923

3. Purification of the hypergly-cemic-glycogenolytic factor from insulin and from gastric mucosa;Sutherland;J Biol Chem,1949

4. The internal secretion of the pancreas;Banting;J Lab Clin Med,1921

5. Aqueous extracts of pancreas III. Some precipitation reactions of insulin;Kimball;J Biol Chem,1923

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