Reactive Infectious Mucocutaneous Eruption with Extensive Cutaneous Involvement

Author:

Anderson Zeynoire1,Fotouhi Audrey2,Tolliver Starling2,Mehregan Darius2

Affiliation:

1. School of Medicine, Wayne State University, Detroit, MI, USA

2. Department of Dermatology, Wayne State University, Detroit, MI, USA

Abstract

Abstract Recently, there has been discussion to reclassify pediatric Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) as drug-induced epidermal necrolysis (DEN), separating it from infectious etiologies and redefining pediatric mucocutaneous eruptions as either reactive infectious mucocutaneous eruption (RIME) or DEN. In this report, we describe a previously healthy 4-year-old girl with rapidly progressive mucocutaneous blistering involving four mucosal membranes and 37.5% of total body surface area (BSA) following a prodromal rhinovirus and enterovirus infection. The symptoms occurred in the absence of an inciting medication and improved with only supportive care. This case illustrates a rare occurrence of RIME with TEN-like BSA involvement, prompting a review of the literature exploring the relationship between BSA involvement in RIME and its influence on patient outcomes. Findings support the proposed reclassification of SJS/TEN as DEN and postinfectious mucocutaneous eruptions as RIME.

Publisher

Medknow

Reference13 articles.

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