Statin-Induced Rhabdomyolysis: A Rare Case

Abstract

ABSTRACT Statins are a group of lipid-lowering agents currently used as mainstay agents in the primary and secondary prevention of atherosclerotic cardiovascular heart disease. Rhabdomyolysis is one of the rare adverse effects of statin therapy, the incidence of which increases in the presence of risk factors. We report a rare case of statin-induced rhabdomyolysis presenting with acute kidney injury (AKI) requiring dialysis in the absence of risk factors. A 58-year-old diabetic and hypertensive female presented with pain and weakness of lower limbs, difficulty in walking, shortness of breath, and decreased urine output. She was receiving statin therapy for the past 1 week. Her blood investigations showed elevated creatine phosphokinase (CPK) and renal parameters. Electromyography and magnetic resonance imaging of thigh and calf muscles were suggestive of myositis. Statin was withdrawn and hemodialysis was done. The patient recovered gradually with no residual deficit. Statin-induced rhabdomyolysis is a rare but serious adverse effect requiring timely management. CPK levels along with thorough history and physical examination are useful to establish the diagnosis. Treatment is hydration and supportive therapy when diagnosed early. Hemodialysis is required in severe cases with AKI.