Comparative analysis of antibiotic prescription and resistance patterns in the management of pediatric urinary tract infections

Abstract

Abstract: INTRODUCTION: Urinary tract infections (UTIs) exhibit a significant prevalence rate in the pediatric population. Antibiotic therapy is a commonly recommended treatment option. Our objective was to investigate the resistance pattern of antibiotics in relation to the prescribed drugs among pediatric patients. MATERIALS AND METHODS: This was a retrospective analysis of pediatric patients with diagnosed UTIs. A total of 100 samples were analyzed for culture and sensitivity. RESULTS: Escherichia coli (33%) was the most common organism isolated, followed by Klebsiella (27%) and Enterococcus (12%). Ceftriaxone (CTR) (85%) was the most commonly prescribed drug, followed by cefixime (CFM) (32%) and ciprofloxacin (25%). The overall resistance pattern of antibiotics to pathogens isolated was highest for cefoperazone (51%), nitrofurantoin (36%), amikacin (28%), and gentamicin (24%). The lowest resistance was observed for vancomycin (0%). The overall sensitivity was highest for imipenem (65%) and piperacillin-tazobactam (50%). The lowest sensitivity was observed for cefotaxime and ceftazidime. CONCLUSION: CTR and CFM were the commonly prescribed drugs for pediatric UTI treatment due to their low resistance rate and adequate sensitivity, high efficacy, well-tolerance, and convenient administration.