Obesity in Renal Transplantation

Abstract

Obesity has surged as a formidable global public health concern, with its prevalence nearly tripling over the past 40 years. Concurrently, the burden of kidney disease remains substantial, with obesity emerging as a significant risk factor. Transplantation is a life-saving intervention for patients with end-stage kidney disease living with obesity. However, it introduces a dual-edged sword, decreasing the risk of mortality related to dialysis while still leaving cardiovascular disease as one of the leading causes of death in transplant recipients. The relationship between obesity and transplantation is a multifaceted challenge demanding concerted efforts from health-care providers, researchers, and policymakers to navigate. While transplantation offers hope and improved quality of life for many, the weight of obesity cannot be underestimated. This review provides a comprehensive assessment of the intricate interplay between obesity and transplantation, with a particular focus on kidney transplantation. Through this review article, we want to reiterate the critical role of weight management, lifestyle modifications, and medical interventions in optimizing transplantation outcomes for individuals with obesity. By comprehensively addressing these issues, we aim to contribute to the development of a holistic approach that minimizes the risks while maximizing the benefits of transplantation for this vulnerable population.