Primary acalvaria an orphan disease: Case report and review of literature

Abstract

Abstract Acalvaria is a very rare congenital anomaly; thus, it is considered to be an orphan disease and is characterized by complete or partial absence of flat calvaria bones, lax skull, dura mater, and associated muscles. In this report, we describe a case of female neonate with primary acalvaria finding on neuroimaging associated with cleft palate.