Risk of Silico-Tuberculosis in Miners: A Systematic Review and Meta-Analysis

Abstract

Context: Tuberculosis (TB) and Silicosis are public health problems with high morbidity and mortality. They also exist as comorbidities and are highly prevalent among mine workers. Aims: This study aims to estimate the risk of TB in miners with silicosis than in miners not having silicosis. Methods and Material: This systematic review was conducted by literature search using PubMed, and EMBASE for studies published from 1st Jan 2017 till 20th July 2022. From the data obtained using relevant keywords for the search, a total of 345 articles were selected for screening after applying our inclusion-exclusion criteria and removing duplicates. PRISMA guidelines were followed. items JBI critical appraisal checklist for cross-sectional studies was used for assessment of the risk of bias. The odds ratio was used to estimate the strength of the association. Results: After extensive screening, four studies have met our selection criteria. The meta-analysis of those studies revealed that the prevalence of TB in miners with silicosis is 27.11% while the prevalence of TB in miners with non-silicosis is 16.75%. The estimated pooled odds ratio (fixed effect model) is 1.34 (95% CI 1.01 – 1.76). Conclusions: The present study reveals that there is an increased risk of TB in miners with Silicosis. Newer initiatives must be taken to prevent TB in miners.