Serum Amylase Levels in T2DM Patients: Surrogate Biomarker of Cardiometabolic Status

Abstract

Abstract Introduction: Diabetes mellitus with hyperglycaemia is a chronic metabolic disorder. The endocrinal function of the pancreas is altered in diabetes mellitus. There is a close anatomic and functional relationship between the exocrine and endocrine portions of the pancreas. The current study was conducted to evaluate the blood glucose and serum amylase levels in type 2 diabetic patients as they represent the two functional aspects of the gland. The aim of the study was to determine the serum amylase and serum lipase in type 2 diabetic patients and to compare and correlate these parameters with those of age- and sex-matched healthy controls. Methodology: Already diagnosed 300 type 2 diabetes mellitus patients have been included in our study as cases and 50 healthy individuals attending the outpatient department have been included as controls. Fasting venous samples have been collected from cases and controls and analysed for blood glucose, lipid profile, renal function test, liver function test, serum amylase and lipase. The results were analysed using Student’s t-test and correlation coefficient. Results: Low levels of serum amylase were observed in type 2 diabetic patients and the values were statistically significant with P < 0.005. The levels of total cholesterol, triglyceride and low-density lipoprotein cholesterol were compared among both the groups and values were significantly higher in cases compared to the controls with P < 0.05, <0.001 and <0.05, respectively. The high-density lipoprotein (HDL) levels were found to be lower in cases with the P < 0.001. Conclusion: In our study, it was observed that, as the blood glucose levels are higher in type 2 diabetic patients, the serum amylase levels were lower significantly. There was a positive correlation between the HDL and serum amylase values, which signifies the role of amylase as an additional and surrogate biomarker for monitoring cardiometabolic status.