Pharmacognostical standardization of Coccinia grandis (L.) Voigt root

Abstract

Abstract Introduction: Coccinia grandis is known for its hypoglyceamic and antidiabetic activities. Various parts of the plant have been reported to possess potential therapeutic activity through literature survey. The goal of this study is to identify this traditional medicine by evaluating the pharmacognostic and phytochemical properties of C. grandis roots. Macro-microscopic features, powder microscopic analysis and histochemical screening assist the proper discrimination between species within the genus Coccinia. Materials and Methods: Pharmacognostical studies such as macroscopic, anatomical characters of root, powder microscopy and histo-chemistry were performed. Phytochemical characteristics of root was determined by HPTLC methods. Results: Pharmacognostical studies provided accurate authentication of the root sample. Histochemical study confirmed the presence of alkaloids, starch grains, oil globules, phenolics, lignin, etc., in the root. HPTLC profiling revelaed chemical fingerprint of the root sample. Discussion and Conclusion: This study revealed the macro-microscopical properties and phytochemical characteristics of C. grandis. The presence of therapeutic compounds in the root revealed in histochemical localisation can be attributed to the antidiabetic, hypoglyceamic and antioxidant activities of the plant.