Effect of Lifestyle Choices on Cerebrospinal Fluid Pulsations

Abstract

ABSTRACT Cerebrospinal fluid (CSF) flow plays a critical role in clearing metabolic waste from the brain. The flow depends on several factors, including cardiac and respiratory oscillations. The process of CSF pulsations also follows a circadian pattern and plays a central role in maintaining the homeostasis of the brain and the central nervous system (CNS). Any disruption to this flow triggers a homeostatic imbalance in the CNS and could increase the risk of several chronic conditions, including Alzheimer’s disease. This commentary highlights recent research to articulate the importance of CSF flow and provides insights into the drivers of the CSF flow. Based on the evidence, the relative importance of respiratory pulsations’ role in CSF flow is highlighted. Specifically, the role of slow breathing and sleep quality and a perspective on the implications for lifestyle choices and future research are highlighted.