Affiliation:
1. Department of Radiation Oncology, St.
John's Medical College and Hospital, Bengaluru,
Karnataka
Abstract
Abstract
Introduction: Combined modality therapy
is the standard of care in locally advanced
head-and-neck cancer (HNC). The incidence of acute
toxicities increases with additional therapy. The
present study investigated the incidence and
patterns of mucositis, dysphagia, aspiration,
feeding tube use, admission for supportive care,
and treatment compliance in patients with HNC
treated curatively with radiation therapy (RT)
with or without chemotherapy. Methods and
Material: A retrospective review of 164
consecutive HNC patients treated with RT at St.
John's Medical College Hospital, Bengaluru, from
January 2013 to June 2017 was done. Results: A
total of 148 HNC patients were treated with a
curative intent and 122 (82.4%) were locally
advanced HNC. Combined Modality treatment was
received by 119 (80.4%) patients. Eighty-four
(56.7%) patients were treated by concurrent
chemo-radiation. IMRT technique was used in 125
(84.5%) patients. The incidence of grade 3-4
mucositis, dysphagia and aspiration was 25%, 46%,
and 10%, respectively. Nasogastric tube feeding
was necessitated in 18.9% (n=28) and 27% (n = 40)
required inpatient admission for supportive care.
Twenty-nine (19.6%) patients did not complete
planned RT dose and 46 (31%) patients had
unscheduled RT break (>2days). Fifty-six
(66.7%) patients did not receive planned
chemotherapy. Conclusions: Acute toxicity due to
RT in HNC remains a challenge despite using modern
techniques. A significant proportion of patients
require supportive therapy for more than 12 weeks
and did not complete the scheduled
treatment.
Funder
the Department of
Radiation Oncology, St John’s Medical College and
Hospital, Bengaluru, India
Cited by
16 articles.
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