Laparoscopic Roux-En-Y gastric bypass versus mini-gastric bypass for the treatment of morbid obesity and effect on glucagon-like peptide-1 level: a randomized comparative study

Author:

Kandel Mohamed M.1,Elkeleny Mostafa R.2,Header Doaa A.3,Korayem Islam M.2,Hassan Mohamed M.2

Affiliation:

1. Department of Surgery, Faculty of Medicine, Port Said University, Port Said, Egypt

2. Department of Surgery, Faculty of Medicine, Alexandria University, Alexandria

3. Department of Internal Medicine, Gastroenterology Unit, Faculty of Medicine, Alexandria University

Abstract

Background The gold standard malabsorptive technique for patients who are morbidly obese that promotes sustained weight loss is laparoscopic Roux-en-Y gastric bypass (LRYGB). An alternative that has gained popularity is laparoscopic mini-gastric bypass (LMGB), which has the advantages of being more technically straightforward, needing less time during surgery, and having a higher food tolerance. This study compares the short-term effects of LMGB and LRYGB on weight reduction and postoperative levels of glucagon-like peptide-1 (GLP-1). Methods This prospective study included 50 morbidly obese patients who were randomly assigned to receive either LRYGB or LMGB, with 25 patients/group in the period from March 2020 to February 2021. Results Group B experienced a much shorter hospital stay and operation time than group A. There was no discernible difference between the two groups in terms of intraoperative errors or postoperative problems. Throughout the follow-up period, the patients’ weights and BMI dramatically fell in both groups, with the LMGB group seeing a much larger mean excess BMI reduction percent. Preoperative comorbidities were significantly resolved in both operations, and there was no discernible difference between the two groups. GLP-1: Following surgery, both groups exhibit a noteworthy rise in postprandial GLP-1 levels. Conclusions Compared with LRYGBP, the LMGB technique produced a greater weight loss with a similar efficiency on metabolic control.

Publisher

Egyptian Knowledge Bank

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