Author:
Hambire Chaitali,Hambire Umesh
Abstract
Measurement of head circumference 2 standard deviations above the age-related mean is called megalencephaly and macrocephaly. A distinction between these two entities is appropriate for proper clinical workup, overall prognosis, and treatment. Macrocephaly is a nonspecific clinical finding without implications about the underlying cause. Megalencephaly is an increased growth of cerebral structures related to dysfunctional anomalies during the various steps of brain development in the neuronal proliferation and/or migration phases or as a consequence of postnatal abnormal events.