Association between anti-Helicobacter pylori immunoglobulin G status and coronary artery disease among hypertensives: Myth or fact?

Abstract

Abstract Background: Chronic persistent inflammation associated with Helicobacter pylori (H. pylori) infection accelerates vascular complications which are prone to cause atherogenesis and coronary artery disease (CAD). This study was undertaken to assess the significance of the association between H. pylori immunoglobulin G (IgG) serostatus and the occurrence of CAD among hypertensives. Materials and Methods: A total of 90 hypertensive subjects without stroke and CAD symptoms were tested for serum H. pylori IgG. Their electrocardiogram and echocardiogram (ECHO) outcomes were analyzed after 3 months. Results: Among the 90 subjects, 52 (57.8%) were H. pylori IgG positive. The adjusted odds ratio for abnormal ECHO outcome and H. pylori IgG positivity was 2.494. There was a positive correlation between H. pylori IgG positivity, sedentary lifestyle, alcoholism, and elevated serum C-reactive protein and abnormal ECHO findings suggestive of CAD. Conclusions: This study found a positive correlation between H. pylori IgG seropositivity and abnormal ECHO outcomes. The prevention of CAD with antimicrobial therapy for H. pylori is simple and innovative. Lifestyle modification and hand hygiene can obviate the adverse circumstances of CAD to some extent.