Dual bombard by Cytomegalovirus and Mycobacterium tuberculosis in a renal transplantee

Author:

Balachander Cinthujah1,Ananthapadmanabasamy Indira2,Viswanathan Ramasubramanian3,Santhanakumarasamy Poongodi1

Affiliation:

1. Department of Microbiology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India

2. Department of Virology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India

3. Department of Nephrology, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India

Abstract

Abstract In the first year following an organ transplant, more than 80% of patients encounter a minimum of one occurrence of infection. Here, we report a case of coinfection of the Cytomegalovirus (CMV) and Mycobacterium tuberculosis (MTB) in a kidney transplantee. Computed tomography chest (CT chest) showed bilateral ground-glass opacities. By Cytomegalovirus DNA polymerase chain reaction, 9360 copies were detected in plasma. Cartridge-based nucleic acid amplification test from bronchial washings tested positive for MTB with very low-level resistance to rifampicin. He was started on category-I antitubercular therapy without rifampicin and intravenous valganciclovir. The clinical status of the patient improved after 1 month of treatment.

Publisher

Medknow

Reference14 articles.

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2. Current trends in kidney transplantation in India;Shroff;Indian J Urol,2016

3. Arare case of Cytomegalovirus, Scedosporium apiospermum and Mycobacterium tuberculosis in a renal transplant recipient;Rathi;BMC Infect Dis,2014

4. Infections in the first year after renal transplant;Saad;Medicina (B Aires),2020

5. Long-term infectious complications of kidney transplantation;Agrawal;Clin J Am Soc Nephrol,2022

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