Affiliation:
1. Departments of General Medicine, Government Medical College and Hospital, Chandigarh, India
Abstract
Paraquat (PQ) is a liquid herbicide commercially traded under the name “Gramoxone.” Human ingestion is uncommon but often fatal. Toxicity of PQ is mediated by the generation of reactive oxygen species which damages cell membranes. Apart from local corrosive damage to the gastrointestinal system, the lungs, liver, and kidneys bear the maximum damage. Rarely, PQ may present as spontaneous pneumothorax or pneumomediastinum or both. Herein, we present a case of fatal PQ poisoning where the patient developed pneumomediastinum on the 9th day with multiorgan dysfunction leading to his demise on 12th day. We also take this opportunity to briefly describe the pathogenesis of lung toxicity, the clinical manifestations, and various treatment strategies being explored in the different parts of the world, as no specific antidote is available till date.
Reference15 articles.
1. Paraquat: The poison potion;Sukumar;Indian J Crit Care Med,2019
2. Review of a case of paraquat poisoning in a tertiary care rural-based ICU;Sharma;Indian J Crit Care Med,2019
3. Pneumoperitoneum from pneumomediastinum in paraquat poisoning;James;Trop Doct,2021
4. Paraquat poisoning presenting as the “Daisley Barton syndrome”;Chaudhuri;Indian J Respir Care,2020
5. A case of paraquat poisoning presenting with spontaneous pneumothorax and pneumomediastinum;Sahoo;Cureus,2020