Cell death pathways in inflammatory bowel disease

Abstract

Intestinal inflammatory disease (IBD) is a chronic intestinal disorder that includes Crohn’s disease and ulcerative colitis. In recent years, its incidence has been increasing, but there is still no breakthrough in its treatment. Cell death was divided into programmed and nonprogrammed cell death (PCD). PCD mainly includes ferroptosis, apoptosis, necroptosis, pyroptosis, and autophagy, while non-PCD refers to necrosis. Increasing evidence shows that PCD, such as ferroptosis and autophagy, plays an important regulatory role in intestinal diseases, which may be involved in the occurrence and progression of IBD and can be used as a therapeutic target for the disease. This article reviews recent studies on ferroptosis, apoptosis, necroptosis, pyroptosis, and autophagy associated with IBD, combs the regulatory mechanisms of PCD in IBD, and summarizes the corresponding therapeutic drugs and new materials, aiming to provide new directions and treatments for IBD research.