Pseudotumor Cerebri Following Kidney Transplant

Abstract

Pseudotumor cerebri (PTC) is a condition characterized by raised intracranial pressure, normal cerebrospinal fluid contents, and normal brain parenchyma on imaging. In this report, we present a 9-year-old boy with a native kidney disease of familial steroid-resistant nephrotic syndrome due to homozygous NPHS2 mutation, who received a kidney allograft from a living-related donor and developed PTC 3 years after transplant. Ongoing medications included mycophenolate mofetil, cyclosporin, and prednisolone as immunosuppressants. This case describes the resolution of PTC after switching to tacrolimus from cyclosporin. Patients who undergo renal transplantation and are on treatment modalities, including cyclosporine, are at risk of PTC, and prompt evaluation and urgent treatment may prevent blindness.