Expression of Mutant BMPR‐II in Pulmonary Endothelial Cells Promotes Apoptosis and a Release of Factors that Stimulate Proliferation of Pulmonary Arterial Smooth Muscle Cells
Author:
Affiliation:
1. Department of MedicineUniversity of Cambridge School of Clinical MedicineAddenbrooke's and Papworth HospitalsCambridgeUnited Kingdom
Funder
British Heart Foundation
European Commission
Publisher
Wiley
Subject
Pulmonary and Respiratory Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.4103/2045-8932.78100
Reference25 articles.
1. Primary pulmonary hypertension;Runo JR;Lancet,2003
2. Heterozygous germline mutations in BMPR2, encoding a TGF‐beta receptor, cause familial primary pulmonary hypertension;Lane KB;Nat Genet,2000
3. Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3‐cM region on chromosome 2q33;Deng Z;Am J Respir Crit Care Med,2000
4. Mutations of the TGF‐beta type II receptor BMPR2 in pulmonary arterial hypertension;Machado RD;Hum Mutat,2006
5. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR‐II, a receptor member of the TGF‐beta family;Thomson JR;J Med Genet,2000
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