Case of childhood laryngeal papillomatosis with metastatic carcinoma esophagus in adulthood

Author:

Shetty Nishitha1,Prabhash Kumar1,Joshi Amit1,Sayed Suhail I.2,Sharma Shilpi2,Noronha Vanita1,Deshmukh Anuja2,Chaukar Devendra2,Kane S3,D′cruz Anil K.2,

Affiliation:

1. Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

2. Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

3. Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Abstract

AbstractA young male patient was diagnosed to have laryngeal papillomas at the age of 3 years for which he underwent permanent tracheostomy and also multiple surgical and laser excision procedures. Then, later in life, the patient had progressive breathlessness and dysphagia. On examination, he had supraclavicular lymphadenopathy showing squamous carcinoma pathology. Since laryngeal papillomas have a high propensity to transform into laryngeal squamous cell carcinoma, he was first evaluated for laryngeal carcinoma which was negative. Esophagoscopy showed a growth in the esophagus, the biopsy of which was positive for squamous malignant cells. Patient was then started on palliative chemotherapy with combination of paclitaxel and carboplatin, and at progression with weekly nanoxel with stable disease. This is a rare case of childhood laryngeal papillomatosis progressing to metastatic esophageal carcinoma. This case has been presented to highlight the fact that patients with laryngeal papillomas are not only at high risk of progressing to laryngeal carcinoma but can also have other malignancies of the upper aerodigestive tract and lung. Most of them have been correlated to human papilloma virus (HPV), but in our patient HPV DNA was negative.

Publisher

Georg Thieme Verlag KG

Subject

Oncology,Pediatrics, Perinatology, and Child Health

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Human Papillomavirus Laryngeal Tracheal Papillomatosis;Journal of Pediatric Health Care;2014-09

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