Influence of bisphenol A on spermatological parameters of New Zealand White Rabbits

Abstract

This study aimed to investigate the possible reproductive toxicity dose of bisphenol A (BPA) in male New Zealand white rabbits. Prior to the experiment, male rabbits (n = 24) were acclimatized to laboratory conditions and trained for semen collection for 14 days. After the training period, rabbits were divided into 4 groups of 6: positive controls and 3 different doses of BPA (10, 20 and 100 mg/kg/day). All treatments were administered by oral gavages for 9 weeks following the training period. At the end of the study, BPA negatively affected the serum testosterone, testicular superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA). Sperm concentrations and percent progressive motility were significantly declined in BPA treated rabbits. LOAEL value of BPA for reproductive parameters was 10 mg/kg/day.