Emerging Pathogenetic Mechanisms of the Implant-Related Osteomyelitis by Staphylococcus Aureus-Reference-Cited by-同舟云学术

Emerging Pathogenetic Mechanisms of the Implant-Related Osteomyelitis by Staphylococcus Aureus

Published:2011-09 Issue:9 Volume:34 Page:781-788
ISSN:0391-3988
Container-title:The International Journal of Artificial Organs
language:en
Short-container-title:Int J Artif Organs

Author:

Montanaro Lucio¹²,Testoni Francesca¹,Poggi Alessandro¹³,Visai Livia⁴⁵⁶,Speziale Pietro⁴,Arciola Carla Renata¹²

Affiliation:

1. Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna - Italy

2. Department of Experimental Pathology, University of Bologna, Bologna - Italy

3. Medicine and Surgery School, University of Modena and Reggio Emilia, Modena - Italy

4. Department of Biochemistry, University of Pavia, Pavia - Italy

5. Center for Tissue Engineering (C.I.T.), University of Pavia, and Salvatore Maugeri Foundation IRCCS, Pavia - Italy

6. International Center for Studies and Research in Biomedicine (I.C.B.) - Luxembourg

Abstract

Implant-related osteomyelitis is a severe and deep infection of bone that arises and develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis, whether implant-related or not. Bone is an optimal substratum for S. aureus, since this bacterium expresses various adhesins by which can adhere to bone proteins and to the biomaterial surfaces coated with the proteins of the host extracellular matrix. S. aureus is able not only to colonize bone tissues, but also to invade and disrupt them by entering bone cells and inducing cell death and osteolysis. Here we illustrate the pathogenetic mechanisms that can explain how the osteomyelitis sets in and develops around an implant.

Publisher

SAGE Publications

Subject

Biomedical Engineering,Biomaterials,General Medicine,Medicine (miscellaneous),Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.5301/ijao.5000052

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