Standardization of the Modified Rodnan Skin Score for Use in Clinical Trials of Systemic Sclerosis

Author:

Khanna Dinesh1,Furst Daniel E.2,Clements Philip J.2,Allanore Yannick3,Baron Murray4,Czirjak Lazlo5,Distler Oliver6,Foeldvari Ivan7,Kuwana Masataka8,Matucci-Cerinic Marco9,Mayes Maureen10,Medsger Thomas11,Merkel Peter A.12,Pope Janet E.13,Seibold James R.14,Steen Virginia15,Stevens Wendy16,Denton Christopher P.17

Affiliation:

1. University of Michigan Scleroderma Program, Ann Arbor, Michigan - USA

2. University of California, Los Angeles (UCLA), Los Angeles, California - USA

3. Paris Descartes University, Rheumatology A Department, Cochin Hospital, Paris - France

4. Department of Medicine, McGill University, Division of Rheumatology, Jewish General Hospital, Montréal - Canada

5. Department of Immunology and Rheumatology, University of Pécs, Pécs - Hungary

6. Division of Rheumatology, University Hospital Zurich, Zurich - Switzerland

7. Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg - Germany

8. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo - Japan

9. Department of Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence - Italy

10. University of Texas McGovern Medical School, Houston, Texas - USA

11. University of Pittsburgh, Pittsburgh, Pennsylvania - USA

12. University of Pennsylvania, Philadelphia, Pennsylvania - USA

13. Deparment of Medicine, University of Western Ontario, London, Ontario - Canada

14. Scleroderma Research Consultants LLC, Litchfield, Connecticut - USA

15. Georgetown University, Washington DC - USA

16. Division of Rheumatology, St. Vincent's Hospital, Melbourne - Australia

17. Centre for Rheumatology, Royal Free and University College London Medical School, London - UK

Abstract

The modified Rodnan skin score (mRSS) is a measure of skin thickness and is used as a primary or secondary outcome measure in clinical trials of systemic sclerosis (scleroderma). This state-of-art review provides a historical perspective of the development of the mRSS, summarizes the performance of mRSS as an outcome measure, provides guidance on assessing mRSS, and makes recommendations for incorporation of the mRSS into clinical trials.

Publisher

SAGE Publications

Subject

Immunology,Rheumatology,Immunology and Allergy

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