Efficacy and Safety of Long-term Tolvaptan Treatment in a Patient with SCLC and SIADH-Reference-Cited by-同舟云学术

Efficacy and Safety of Long-term Tolvaptan Treatment in a Patient with SCLC and SIADH

Published:2015-03 Issue:2 Volume:101 Page:e51-e53
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Bordi Paola¹,Tiseo Marcello¹,Buti Sebastiano¹,Regolisti Giuseppe²,Ardizzoni Andrea¹

Affiliation:

1. Medical Oncology Unit, University Hospital of Parma, Parma - Italy

2. Pathophysiology of Acute and Chronic Renal Failure Unit, Department of Clinical and Experimental Medicine, University of Parma, University Hospital of Parma, Parma - Italy

Abstract

Hyponatremia frequently occurs in patients with cancer and is mostly due to a syndrome of inappropriate antidiuresis caused by ectopic secretion of antidiuretic hormone (SIADH). Small cell lung cancer presents with SIADH in approximately 11%-15% of cases. Recently, a new class of drugs, vasopressin V2-receptor antagonists (vaptans), emerged as a promising treatment for SIADH, but efficacy and safety data in cancer patients are lacking. We present a case of SIADH, heralding small cell lung cancer and persisting after apparent complete remission of primary tumor following chemotherapy/radiotherapy, in a patient who underwent long-term treatment with tolvaptan without any serious adverse effects.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.5301/tj.5000249

Reference15 articles.

1. Diagnosis and Management of Hyponatremia in Cancer Patients

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