Near-Infrared Fundus Autofluorescence in Multiple Evanescent White-Dot Syndrome

Abstract

Purpose To report the near-infrared fundus autofluorescence (NIR-FAF) pattern in 2 cases of multiple evanescent white-dot syndrome (MEWDS). Methods Three consecutive patients with MEWDS underwent a complete ophthalmologic examination, including color photograph, blue-light fundus autofluorescence, NIR-FAF, fluorescein angiography, and indocyanine green angiography (ICGA). Main outcome measure was the identification of NIR-FAF pattern. Results Fluorescein angiography showed patchy hyperfluorescence of the whitish dots. Indocyanine green angiography showed hypofluorescent spots throughout the examination. Blue-light fundus autofluorescence disclosed a speckled pattern without extension to the foveal area, whereas NIR-AF showed several hypoautofluorescent lesions involving also the fovea, which corresponded to the whitish dots visible on biomicroscopy and to the hypofluorescent lesions detectable on ICGA. Conclusions Near-infrared fundus autofluorescence is characterized by hypoautofluorescent spots corresponding to the inflammatory lesions typical of MEWDS and can be considered as a valuable noninvasive technique to diagnose and monitor patients with MEWDS.