The role of chemokine CC ligand 20 in patients with liver cirrhosis and hepatocellular carcinoma

Author:

Soliman Hanan H.1,Nagy Hala2,Kotb Nesreen3,El-Din Mohamed A. Alm4

Affiliation:

1. Department of Tropical Medicine and Infectious Diseases, Tanta University Hospitals, Tanta Faculty of Medicine, Tanta - Egypt

2. Department of Clinical Pathology, Tanta University Hospitals, Tanta Faculty of Medicine, Tanta - Egypt

3. Department of Internal Medicine, Tanta University Hospitals, Tanta Faculty of Medicine, Tanta - Egypt

4. Department of Clinical Oncology, Tanta University Hospitals, Tanta Faculty of Medicine, Tanta - Egypt

Abstract

Background and aim To evaluate the role of chemokine CC ligand 20 (CCL20) as a biomarker for hepatocellular carcinoma (HCC). Patients and methods Ninety patients in four groups were enrolled in this prospective cross-sectional study: 30 with HCC (group I), 30 with liver cirrhosis (group II), 15 with hepatitis C virus infection (group III), and 15 healthy blood donors as controls. Alpha fetoprotein (AFP), CCL20 and vascular endothelial growth factor (VEGF) were measured in all groups. Results Serum levels of CCL20 were significantly different among the study groups (F=230.979, p<0.001). The highest level was found in HCC patients (57.305 ± 6.386 pg/mL) followed by patients with cirrhosis (45.999 ± 5.165 pg/mL) compared with 22.781 ± 5.986 pg/mL and 18.585 ± 3.554 pg/mL in asymptomatic patients with HCV infection and controls, respectively. In HCC patients, CCL20 significantly correlated with VEGF (r=0.559, p=0.001), AFP (r=0.814, p<0.001), Child score (r=0.748, p<0.001), and tumor size (r=0.825, p<0.001). The cutoff value of CCL20 for the detection of HCC in HCV-infected patients was 54 pg/mL with 93.1% accuracy, 89.6% negative predictive value, 92.6% positive predictive value, 83.3% sensitivity, and 93.3% specificity. In patients with cirrhosis, CCL20 significantly correlated with VEGF (r=0.455, p=0.011), AFP (r=0.975, p<0.001), and Child score (r=0.977, p<0.001). Conclusion CCL20 may be used for the detection of HCC in HCV-infected patients with comparable specificity and higher sensitivity than AFP.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

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