Association of TNF-α Genetic Polymorphisms with Hepatocellular Carcinoma Susceptibility: A Case-Control Study in a Han Chinese Population

Author:

Chen Xiangmei1,Zhang Ling2,Chang Yibin1,Shen Tao1,Wang Ling1,Zhuang Hui1,Lu Fengmin1

Affiliation:

1. Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing - PR China

2. Department of Hepatobiliary Pancreatic Surgery, Henan Cancer Hospital, Zhengzhou - PR China

Abstract

The single nucleotide polymorphisms (SNPs) within the tumor necrosis factor-α (TNF-α) gene promoter region have been reported to be associated with susceptibility to various types of cancers. A case-control study (126 hepatocellular carcinoma [HCC] patients and 126 normal controls) was conducted to elucidate their possible association with the risk of hepatitis B virus (HBV)-related HCC in a Han Chinese population. TNF-α polymorphisms -1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A were genotyped by polymerase chain reaction (PCR) and direct DNA sequencing. Disease associations were analyzed by the chi-square test or Fisher's exact test. When analyzed by overall groups, no significant differences in genotype and allele distributions were observed between the control and cases. However, stratified analysis according to sex showed that the frequency of the homozygous C allele of the -857 polymorphism was lower in female cases than in female controls (62.9% vs. 88.9%, p=0.026). In addition, further haplotype analysis revealed that the TCCGA (-1031/-863/-857/-308/-238) was more frequent in controls than cases (p=0.018; odds ratio = 0.266; 95% confidence interval, 0.083–0.857). These results indicated that the TNF-α-857C/T polymorphism may modify HBV-related HCC risk among women, and the haplotype TCCGA (-1031/-863/-857/-308/-238) may account for a decreased susceptibility to HCC development in the Han Chinese population. Additional studies in patients with different ethnic backgrounds are needed to validate these finding and to further explore the genetic pathogenesis of HBV-related HCC.

Publisher

SAGE Publications

Subject

Cancer Research,Clinical Biochemistry,Oncology,Pathology and Forensic Medicine

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