Role of Functional Imaging in Treatment Plan Optimization of Stereotactic Body Radiation Therapy for Liver Cancer

Author:

De Bari Berardino1,Jumeau Raphael1,Deantonio Letizia12,Adib Salim3,Godin Sarah1,Zeverino Michele4,Moeckli Raphael4,Bourhis Jean1,Prior John O.3,Ozsahin Mahmut1

Affiliation:

1. Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland

2. Current address: Radiotherapy Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara - Italy

3. Nuclear Medicine and Molecular Medicine Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland

4. Medical Physics, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland

Abstract

We report the first known instance of the clinical use of 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) for the optimization of radiotherapy treatment planning and for the follow-up of acute toxicity in a patient undergoing stereotactic body radiation therapy for hepatocellular carcinoma. In our experience, HBS allowed the identification and the sparing of more functioning liver areas, thus potentially reducing the risk of radiation-induced liver toxicity.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

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